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dimanche, juillet 18 2021

[download pdf] Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization

Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization by Li Di, Edward H Kerns

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  • Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization
  • Li Di, Edward H Kerns
  • Page: 580
  • Format: pdf, ePub, mobi, fb2
  • ISBN: 9780128010761
  • Publisher: Elsevier Science

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Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization. Provides a comprehensive and valuable working handbook for scientists and students in medicinal chemistry Includes expanded coverage of pharmacokinetics fundamentals and effects Contains updates throughout, including the authors’ recent work in the importance of solubility in drug development; new and currently used property methods, with a reduction of seldom-used methods; and exploration of computational modeling methods



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5-Minute Pediatric Consult. Michael Cabana MD, MPH

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5-Minute-Pediatric-Consult.pdf
ISBN: 9781496381767 | 1136 pages | 19 Mb

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  • Michael Cabana MD, MPH
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jeudi, mars 18 2021

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  • JOANOT MARTORELL
  • Número de páginas: 336
  • Idioma: CATALÁN
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La història damor dels protagonistes del Tirant lo Blanc comença amb una gran mentida, com va apuntar Martí de Riquer fa una vintena danys. La diu Diafebus quan parla per primera vegada en privat amb Carmesina i li explica que el seu cosí i amic Tirant ha viatjat fins a Constantinoble només per veure-la a ella, perquè se nha enamorat per totes les coses bones que nha sentit dir. A partir daquí, el cavaller valencià Joanot Martorell (1405/11-1465) construeix una trama amb episodis tan brillants i personatges tan propers i entranyables que han convertit el Tirant lo Blanc (1460-1464) en una novel·la admirada i un clàssic de la literatura universal. Llegir-la esdevé un plaer carregat de diversió encara al segle XXI.Aquesta edició recull els cinquanta-tres capítols seleccionats pel Departament dEnsenyament de la Generalitat de Catalunya com a lectura prescriptiva per al batxillerat.

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Yashiro, jefe de la yakuza, y Dômeki, su guardaespaldas, han cruzado la línea que nunca debieron rebasar. Ahora, ambos habrán de hacer frente a sus contradicciones. Yashiro teme perder a Dômeki aunque, al mismo tiempo, el miedo lo hace alejarse de él. Dômeki ama a su kashira, pero la intensidad de ese amor amenaza con destruir a Yashiro. Mientras, la lucha entre los jefes de mafia tokiota se recrudece. Yashiro, decidido a poner fin a los conflictos de una vez por todas, abandona a sus subordinados para ir en busca de Hirata. Tras hacer caso omiso de las recomendaciones del oyaji Misumi, se dirige hacia una muerte casi segura. ¿Sobrevivirá Yashiro a su duelo con Hirata? La historia se encamina hacia un trágico desenlace… O un nuevo comienzo.

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mercredi, mars 17 2021

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Cómo las mentiras están haciendo a los pobres y a la clase media más pobres. «En 1983, leí Grunch of Giants, escrito por el Dr. R. Buckminster Fuller. Grunch es el acrónimo de GRoss UNiversal Cash Heist que significa "el flagrante atraco universal del efectivo". Grunch of Giants trata sobre cómo los ultrarricos roban el mundo. Falso habla de lo que descubrí sobre los gigantes. Falso es sobre cómo, tú y yo no tenemos que ser víctimas de los gigantes de GRUNCH.» HAZ FRENTE A LO FALSO CON HECHOS DINERO FALSO En 1971, el dólar estadounidense se convirtió en dinero fiduciario. El dinero fiduciario es dinero del gobierno. Padre Rico llamó al dinero del gobierno #dinero falso#. El dinero falso hace a los ricos más ricos. El problema es que el dinero falso hace que los pobres y la clase media sean más pobres. MAESTROS FALSOS ¿Qué te enseñó la escuela sobre el dinero? ¿Qué sabían tus padres sobre el dinero? ¿Qué sabe tu asesor financiero sobre el dinero? ¿Qué saben nuestros líderes sobre el dinero? ¿Por qué 78% de las personas vive de quincena en quincena? ¿Por qué los estudiantes se tambalean bajo una deuda millonaria de préstamos estudiantiles? ¿Por qué los maestros se ponen en huelga pidiendo más dinero? ACTIVOS FALSOS En 2008 la economía mundial colapsó cuando los activos falsos, hipotecas de bienes raíces de alto riesgo, colapsaron. ¿Siguen los mismos banqueros que vendieron los activos falsos en 2008 vendiendo activos falsos para ti, para mí y para los planes de pensión de los empleados? ¿Por qué hay tantas pensiones con fondos insuficientes? ¿Cuántos baby boomers se quedarán sin dinero en la jubilación? ¿Se aproxima una crisis más grande? ENGLISH DESCRIPTION   Robert Kiyosaki, author of the #1 Personal Finance book of all time ― has built a legacy around simplifying complex and often-confusing subjects like money and investing. He continues to challenge conventional wisdom and asks the questions that will help readers sift through today's information overload to uncover ways to assess what's real… and what isn't. And use truth and facts as a foundation for taking control of their financial lives.   In this new book, Robert fights what’s ‘fake’ and helps readers differentiate between what’s real…and what isn’t.   Robert pulls no punches in his assessment of what is passed off as ‘fact’ or conventional wisdom and believes that a strong foundation, for anything we want to build, needs to start with solid, true information. In today’s uncertain times, creating a secure financial future and the peace of mind that comes with it starts with taking action and taking control.   In FAKE: Fake Money, Fake Teachers, Fake Assets, Robert delivers insights and answers that help ordinary people, who probably haven’t had a lot of financial education, determine what’s ‘real’ and relevant to their financial lives.   Every day we are bombarded with news reports and information and opinions… How do we decipher fact from fiction? How do we differentiate between truth and lies? And determine what’s real… from what isn’t? Kiyosaki believes that it starts with education, financial education designed to make us smarter with our money, and able to fight what’s fake and use what isn’t to secure our financial future.



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  • ISBN: 9780310353577
  • Publisher: Zondervan

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Free ebooks and download Permission Granted: Be Who You Were Made to Be and Let Go of the Rest

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From award-winning blogger Melissa Camara Wilkins, come and find a stunningly simple path to confidence and clarity. All you have to do is give yourself permission to show up as your gloriously imperfect self. Trying to fix yourself is exhausting. But being yourself - that is both possible and life-giving. The key is a simple heart-shift from chasing after perfection to learning to tell a truer story about ourselves, the world, and our place in it. Melissa Camara Wilkins invites you into her journey of discovering the profound simplicity of dropping the pretenses and allowing ourselves to be fully human - flaws and all. This is a story about making life simpler by letting go of who you think you're supposed to be and becoming who you really are. With wit and compassion, Melissa explores how to be present, show up as your real self, and get comfortable in your own skin by aligning the truth inside you with the life you live on the outside. Gain confidence with the freeing practices of dropping the mask, abandoning the experts, and understanding your real assignment. With refreshing honesty and insight, Melissa invites you to move from the either/or dichotomy into a spacious freedom of embracing the both/and - brave and scared, messy and real, gloriously imperfect and absolutely enough. This is your permission slip to be your whole, human self. For everyone who feels the pressure to fit in, measure up, and get it together, Permission Granted is a life-giving invitation to soul-level simplicity.



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Downloading free audio books kindle El Arte de decir NO (English literature) by Hedwig Keller 9788491113317

El Arte de decir NO. Hedwig Keller

El Arte de decir NO


El-Arte-de-decir-NO.pdf
ISBN: 9788491113317 | 128 pages | 4 Mb

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  • El Arte de decir NO
  • Hedwig Keller
  • Page: 128
  • Format: pdf, ePub, fb2, mobi
  • ISBN: 9788491113317
  • Publisher: Obelisco, Ediciones S.A.
Download El Arte de decir NO


Downloading free audio books kindle El Arte de decir NO (English literature) by Hedwig Keller 9788491113317

El Arte de decir NO by Hedwig Keller ¡Basta ya de titubear! Aprende a decir «NO». Gracias a este libro conseguirás en poco tiempo resultados sorprendentes: un «No» pronunciado a tiempo evita malentendidos, discusiones, estrés y mal humor. Además de esclarecer las cosas, facilita un mejor entendimiento entre las personas, generando confianza y aceptación. Con unas cuantas técnicas, consejos y trucos, harás tu vida más fácil, serás más respetado y nadie volverá a aprovecharse de ti. ¡Incluye ejercicios prácticos con los que aprenderás a superar obstáculos y ganar en simpatía!

ARTE DE DECIR NO, EL : Agapea Libros Urgentes
Comprar el libro ARTE DE DECIR NO, EL de Hedwig Kellner, Ediciones Obelisco S.L. (9788497772334) con descuento en la librería online Agapea.com; Ver  Fangoria – El Arte De Decir Que No Lyrics | Genius Lyrics
El Arte De Decir Que No Lyrics: Porque a mi no me gusta perder / Los papeles ni el sitio / Ni escuchar disparates que van / A sacarme de quicio / Mentiras,  EL ARTE DE DECIR NO | HEDWIG KELLNER - Casa del Libro
EL ARTE DE DECIR NO del autor HEDWIG KELLNER (ISBN 9788497772334). Comprar libro completo al MEJOR PRECIO nuevo o segunda mano, leer online  El arte de decir que no | Opinión | Peru21
El arte de decir que no. Muchos sienten vergüenza cada vez que tienen que negarse a aceptar un pedido que, en el fondo, no quieren hacer. El arte de decir no . El Comercio
Decir no a un reconocimiento oficial no es habitual, pero es cada vez más oficial al rechazar la Medalla de Oro al Mérito en las Bellas Artes. El arte de decir NO
Breve repaso de quienes se atrevieron a decir que no. artista Santiago Sierra acaba de declinar el Premio Nacional de las Artes de España. El Arte De Decir Que No by Fangoria on Amazon Music - Amazon.com
Check out El Arte De Decir Que No by Fangoria on Amazon Music. Stream ad- free or purchase CD's and MP3s now on Amazon.com. En busca del Ser: El arte de decir: ¡NO!
El arte de decir: ¡NO! Inmersos en una sociedad en la que interactúan nuestros intereses con el de los demás, aprender a decir no va más allá  EL ARTE DE DECIR - Gandhi
Libro EL ARTE DE DECIR < >: UN PROGRAMA DE EJERCICIOS PARA APRENDER A DECIR NO DE FORMA CONVINCENTE del Autor HEDWIG KELLNER  El arte de decir NO / The Art of Saying NO - by Hedwig Keller - Target
Basta ya de titubear! Aprende a decir «NO». Gracias a este libro conseguiras en poco tiempo resultados sorprendentes: un «No» pronunciado a tiempo evita  El arte de decir no - ABC.es
El dibujante Jan, creador de 'Superlópez, ha sido el último 'agraciado' con una distinción institucional que practica el arte de decir no antes 



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